Dans le dernier numéro du BMJ, du 12décembre 2009, Fiona Godlee consacre son éditorial à la revue systématique Cochrane sur le Tamiflu (oseltamivir). La couverture du journal : "The truth about Tamiflu?".Ce numéro du BMJ publie 6 articles, 2 lettres en plus de la revue systématique sur ce sujet. Il semblerait que tous les essais n'aient pas été publiés, mais ceci me semble normal, sauf si des journaux des essais négatifs se développent, etc…. La conclusion de la revue Cochrane est : "Neuraminidase inhibitors have modest effectiveness against the symptoms of influenza in otherwise healthy adults. The drugs are effective postexposure against laboratory confirmed influenza, but this is a small component of influenza-like illness, so for this outcome neuraminidase inhibitors are not effective. Neuraminidase inhibitors might be regarded as optional for reducing the symptoms of seasonal influenza. Paucity of good data has undermined previous findings for oseltamivir’s prevention of complications from influenza. Independent randomised trials to resolve these uncertainties are needed. "
La position de Fiona est "Between them the articles conclude that the evidence that oseltamivir reduces complications in otherwise healthy people with pandemic influenza is now uncertain and that we need a radical change in the rules on access to trial data. "
Faites-vous une idée rapidement, avant la fin de l'épidémie !
Godlee F. We want raw data, now. BMJ 2009;339:b5405.
